The final image was created in the latest version of ZBrush and uses the all new Polymesh feature. As with most of the newer features in ZBrush Pixologic provide you with an extensive set of ZScripts to help you understand the basics. Polyspheres is no exception. The ZScript is the best way to learn! Run them.
This model utilized 3 different programs: Amapi 6, ZBrush1.5 and Lightwave 7.5. This tutorial also illustrates how you can utilize the best features of different programs. There is no need to slavishly stay in one piece of software.